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Publication Cover

American Journal of Respiratory and Critical Care Medicine

Table of Contents
Volume 199, Issue 4 | February 15 2019
ISSN: 1073-449X | eISSN: 1535-4970
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Editorials

The State of Asthma Research: Considerable Advances, but Still a Long Way to Go
Fernando D. Martinez
pp. 397–399
First Page | Full Text | PDF (465 KB) 
Can We Predict Exacerbations of Asthma?
Malcolm R. Sears
pp. 399–400
First Page | Full Text | PDF (441 KB) | related article 
Sorting Out Nonadherence and Airway Inflammation in Treatment Escalation for Severe Asthma
Bruce G. Bender
pp. 400–402
First Page | Full Text | PDF (524 KB) | related article 
Transcriptome Analysis of Sputum Cells. The Modern Art of Assessing Inflammation
Christian Taube and Sebastian Reuter
pp. 402–404
First Page | Full Text | PDF (452 KB) | related article 
Why Is ORMDL3 on Chromosome 17q21 Highly Linked to Asthma?
Marina Miller and David H. Broide
pp. 404–406
First Page | Full Text | PDF (454 KB) | related article 
New Biologics for Severe Asthma: What Patients, What Agents, What Results, at What Cost?
Klaus F. Rabe
pp. 406–408
First Page | Full Text | PDF (450 KB) | related article 
Ezrin in Asthma: A First Step to Early Biomarkers of Airway Epithelial Dysfunction
Qun Wu and Oliver Eickelberg
pp. 408–410
First Page | Full Text | PDF (449 KB) | related article 
Effects of Anti–IL-5 on Virus-induced Exacerbation in Asthma. Light and Shadow
Marco Contoli and Alberto Papi
pp. 410–411
First Page | Full Text | PDF (437 KB) | related article 
Clinical Significance of Viral Detection in Critically Ill Patients. More Questions Than Answers
Pedro Póvoa and Luís Coelho
pp. 411–413
First Page | Full Text | PDF (444 KB) | related article 

Concise Clinical Reviews

Childhood Asthma: Advances Using Machine Learning and Mechanistic Studies
Sejal Saglani and Adnan Custovic
pp. 414–422
Abstract | Full Text | PDF (825 KB) 
Mechanisms and Management of Asthma Exacerbations
J. Michael Ramsahai, Philip M. Hansbro, and Peter A. B. Wark
pp. 423–432
Abstract | Full Text | PDF (610 KB) 
Role of Biologics in Asthma
Mary Clare McGregor, James G. Krings, Parameswaran Nair, and Mario Castro
pp. 433–445
Abstract | Full Text | PDF (1346 KB) 

Original Articles

Asthma and Allergy

Exacerbation Patterns in Adults with Asthma in England. A Population-based Study
Chloe I. Bloom, Thomas Palmer, Johanna Feary, Jennifer K. Quint, and Paul Cullinan
pp. 446–453
Abstract | Full Text | PDF (679 KB) | related editorial 
Remotely Monitored Therapy and Nitric Oxide Suppression Identifies Nonadherence in Severe Asthma
Liam G. Heaney, John Busby, Peter Bradding, Rekha Chaudhuri, Adel H. Mansur, Robert Niven, Ian D. Pavord, John T. Lindsay, and Richard W. Costello; on behalf of the Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK)
pp. 454–464
Abstract | Full Text | PDF (866 KB) | related editorial 
A Transcriptomic Method to Determine Airway Immune Dysfunction in T2-High and T2-Low Asthma
Michael C. Peters, Lando Ringel, Nathan Dyjack, Rachelle Herrin, Prescott G. Woodruff, Cydney Rios, Brian O’Connor, John V. Fahy, and Max A. Seibold
pp. 465–477
Abstract | Full Text | PDF (1954 KB) | related editorial 
The ORMDL3 Asthma Gene Regulates ICAM1 and Has Multiple Effects on Cellular Inflammation
Youming Zhang, Saffron A. G. Willis-Owen, Sarah Spiegel, Clare M. Lloyd, Miriam F. Moffatt, and William O. C. M. Cookson
pp. 478–488
Abstract | Full Text | PDF (1035 KB) | related editorial 
Predicting Responders to Reslizumab after 16 Weeks of Treatment Using an Algorithm Derived from Clinical Studies of Patients with Severe Eosinophilic Asthma
Eric D. Bateman, Ratko Djukanović, Mario Castro, Janice Canvin, Matthew Germinaro, Robert Noble, Margaret Garin, and Roland Buhl
pp. 489–495
Abstract | Full Text | PDF (659 KB) | related editorial 
Ezrin, a Membrane Cytoskeleton Cross-Linker Protein, as a Marker of Epithelial Damage in Asthma
Man Jia, Xiaoyi Yan, Xinyu Jiang, Yunhui Wu, Jiayan Xu, Yaqi Meng, Yi Yang, Xia Shan, Xiuwedi Zhang, Shan Mao, Wei Gu, Stelios Pavlidis, Peter J. Barnes, Ian M. Adcock, Mao Huang, and Xin Yao
pp. 496–507
Abstract | Full Text | PDF (2542 KB) | related editorial 
Anti–IL-5 in Mild Asthma Alters Rhinovirus-induced Macrophage, B-Cell, and Neutrophil Responses (MATERIAL). A Placebo-controlled, Double-Blind Study
Yanaika S. Sabogal Piñeros, Suzanne M. Bal, Marianne A. van de Pol, Barbara S. Dierdorp, Tamara Dekker, Annemiek Dijkhuis, Paul Brinkman, Koen F. van der Sluijs, Aeilko H. Zwinderman, Christof J. Majoor, Peter I. Bonta, Lara Ravanetti, Peter J. Sterk, and René Lutter
pp. 508–517
Abstract | Full Text | PDF (896 KB) | related editorial 

Critical Care

Clinical Significance of Upper Airway Virus Detection in Critically Ill Hematology Patients
Jérôme Legoff, Noémie Zucman, Virginie Lemiale, Djamel Mokart, Frédéric Pène, Jérôme Lambert, Achille Kouatchet, Alexandre Demoule, François Vincent, Martine Nyunga, Fabrice Bruneel, Adrien Contejean, Séverine Mercier-Delarue, Antoine Rabbat, Christine Lebert, Pierre Perez, Anne-Pascale Meert, Dominique Benoit, Carole Schwebel, Mercé Jourdain, Michael Darmon, Matthieu Resche-Rigon, and Elie Azoulay
pp. 518–528
Abstract | Full Text | PDF (784 KB) | related editorial 

Images in Pulmonary, Critical Care, Sleep Medicine and the Sciences

Pulmonary Lymphatic Perfusion Syndrome
Taizou Hirano, Naoya Fujino, Kei Takase, Hideki Ota, Rie Tanaka, Ryota Saito, Ayumi Suzuki, Koji Okutomo, Teruyuki Sato, Sakiko Kageyama, Tsutomu Tamada, Hisatoshi Sugiura, and Masakazu Ichinose
pp. 529–530
First Page | Full Text | PDF (3250 KB) 
Tracheal Submucosal Lymphovenous Malformation
Michael H. Bourne Jr., Ryan M. Kern, Darin White, and Karthik Balakrishnan
pp. e26–e27
First Page | Full Text | PDF (1130 KB) 

Correspondence

Asthma Information Seeking via Wikipedia between 2015 and 2018: Implications for Awareness Promotion
Craig S. Jabaley, Robert F. Groff IV, and Vikas N. O’Reilly-Shah
pp. 531–533
First Page | Full Text | PDF (3329 KB) 
Environmental Tobacco Smoke Affects Lung Function of Preschoolers with Asthma Even after a Decade
Katariina Lajunen, Satu Kalliola, Anne Kotaniemi-Syrjänen, L. Pekka Malmberg, Anna S. Pelkonen, and Mika J. Mäkelä
pp. 534–536
First Page | Full Text | PDF (552 KB) 
Persistent Reduction of Mucin Production after Bronchial Thermoplasty in Severe Asthma
Ikhlass Haj Salem, Delphine Gras, Philippe Joubert, Louis-Philippe Boulet, Noel Lampron, Simon Martel, Krystelle Godbout, Pascal Chanez, Michel Laviolette, and Jamila Chakir
pp. 536–538
First Page | Full Text | PDF (673 KB) 
High Prevalence of Laryngeal Obstruction during Exercise in Severe Asthma
James H. Hull, Emil S. Walsted, Matt J. Pavitt, Andrew Menzies-Gow, Vibeke Backer, and Guri Sandhu
pp. 538–542
First Page | Full Text | PDF (871 KB) 
Diagnostic Failures in Asthma
Paul A. Bergl
pp. 542–543
First Page | Full Text | PDF (441 KB) 
Reply to Bergl: Diagnostic Failures in Asthma
Shawn D. Aaron; on behalf of all authors
p. 543
First Page | Full Text | PDF (430 KB) 
High Positive End-Expiratory Pressure: Only a Dam against Edema Formation? Probably Not (Again)
Alessandro Santini, Giacomo E. Iapichino, and Alessandro Protti
pp. 543–544
First Page | Full Text | PDF (442 KB) 
Reply to Santini et al.: High Positive End-Expiratory Pressure: Only a Dam against Edema Formation? Probably Not (Again)
Bhushan H. Katira, Wolfgang M. Kuebler, Kim A. Connelly, and Brian P. Kavanagh
p. 544
First Page | Full Text | PDF (430 KB) 

Patient Education/Information Series

Treating Asthma Symptoms with Quick Relief Bronchodilators: Prescription or Over-The-Counter Inhalers
Marianna Sockrider and Maureen George
pp. P7–P8
First Page | PDF (3061 KB) 
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