Publication Cover

American Journal of Respiratory Cell and Molecular Biology

Publishes the most significant and original observations in the area of respiratory and lung cell biology, including cellular, biochemical, molecular, developmental, genetic, and immunologic studies in health and in acute and chronic disorders related to the respiratory system and sleep

Red in Motion

News & Announcements

This call aims to showcase papers that investigate the mechanisms by which environmental climate change-related factors impact lung health and disease either directly, or through interaction with other elements.
Call for Applications for the Editor Apprentice Program.
ATS Journals have waived submission fees.
The 2023 impact factors are now available.
We are thrilled to announce the winners of the 2024 AJRCMB Junior Investigator Awards.
In recognition of their exemplary work, the AJRCMB editors are delighted to present the 2023 Journal Reviewer Award winners.
This page will serve as a hub for all COVID-19 related manuscripts published across all four ATS Journals.

Current Issue Highlights

The present report may serve as a guide for the use of hPAEpCs as an in vitro mimic of alveolar epithelial cells in lung research, highlighting the strengths and potential pitfalls of this system. hPAEpCs can be readily cultured at GLI in Transwells, where they form an intact epithelial barrier with characteristic ion transport function and generate sufficient amounts of cells, protein, and RNA for cell and molecular analyses. As such, hPAEpCs may prove particularly useful for studies of barrier function and drug delivery, ion transport, or fluid clearance.
The authors demonstrate that lung epithelial cells in humans and mice release GDF15 (growth differentiation factor 15), a stress cytokine with proposed roles in stress erythropoiesis, into airspaces and blood in response to pathogen injury. Airspace reconstitution of GDF15 during hemorrhagic lung injury in knockout mice increased plasma levels of GDF15 and circulating erythrocyte counts. The authors speculate that GDF15 release by the lung may act as an extrapulmonary stress response hormone, suggesting a previously unrecognized pathway of lung–blood communication.
Downregulated microRNA-205 in pericytes resulted in the dysfunction of pericytes through activating the Ddx5 (DEAD-box protein 5)/p-Gsk3β/β-catenin axis, promoting the pulmonary hypertension after intrauterine growth restriction (IUGR). These findings provide a new therapeutic target for IUGR-related pulmonary hypertension and throw light on future studies to look for biomarkers to prevent the adverse effects of IUGR.
The authors observed large and significant differences in alternative splicing between bronchial samples of patients with COPD and control subjects, with more events observed in severe than in mild-to-moderate COPD. The changes in the expression of several splicing factors correlated with prevalence of alternative splicing in severe COPD. Alternative splicing can indirectly impact gene expression by changing the relative abundance of protein-coding isoforms potentially influencing pathophysiological changes. The results provide a better understanding of COPD-related alternative splicing changes.

Journal Metrics

Impact Factor
Google h5-index 45
Full-Text Views
~1.6 Million
More Metrics