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American Journal of Respiratory Cell and Molecular Biology

Publishes the most significant and original observations in the area of respiratory and lung cell biology, including cellular, biochemical, molecular, developmental, genetic, and immunologic studies in health and in acute and chronic disorders related to the respiratory system and sleep

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News & Announcements

Call for Applications for the Editor Apprentice Program.
ATS Journals have waived submission fees.
This call focuses on the use and impact of multiple omics technologies associated with respiratory diseases, lung development, and precision medicine strategies.
The 2023 impact factors are now available.
We are thrilled to announce the winners of the 2024 AJRCMB Junior Investigator Awards.
In recognition of their exemplary work, the AJRCMB editors are delighted to present the 2023 Journal Reviewer Award winners.
This page will serve as a hub for all COVID-19 related manuscripts published across all four ATS Journals.

Current Issue Highlights

Although novel models are evolving that capture some or all of the elements of the altered extracellular matrix (ECM) microenvironment in lung diseases, opportunities exist to more fully understand cell–ECM interactions that will help devise future therapeutic targets to restore function in chronic lung diseases. In this perspective article, the authors review evolving knowledge about the ECM’s role in homeostasis and disease in the lung.
The authors’ results suggest that Idiopathic pulmonary fibrosis (IPF)-derived exosomes containing miR-143-5p and miR-342-5p inhibited the de novo fatty acid synthesis pathway in ATII cells. They also induced the profibrotic response in fibroblasts. Pirfenidone and nintedanib improved ATII cell function and inhibited fibrogenesis. This study highlights the importance of exosomes in IPF pathophysiology.
Bronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, is characterized by impaired lung development with sustained functional abnormalities due to alterations in airway and distal lung growth. Whether dysanapsis, the concept of discordant growth of airways and parenchyma, contributes to late respiratory disease in BPD is unknown. This study demonstrates that, in a preclinical rodent model of BPD, antenatal stress causes abnormalities of the central airways and distal lung growth, suggesting that dysanapsis contributes to abnormal lung function in juvenille rats exposed to antenatal endotoxin.
Although important, how mesenchymal cell mechanics regulate alveolar formation and regeneration remains poorly understood. More detailed knowledge about how drebrin responds to mechanical cues and regulates cytoskeletal remodeling will facilitate strategies for alveolar restoration in pulmonary emphysema and fibrosis.

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