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American Journal of Respiratory Cell and Molecular Biology

Publishes the most significant and original observations in the area of respiratory and lung cell biology, including cellular, biochemical, molecular, developmental, genetic, and immunologic studies in health and in acute and chronic disorders related to the respiratory system and sleep

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News & Announcements

The 2023 impact factors are now available.
We are looking to recruit additional members of the Early Career Group.
We are thrilled to announce the winners of the 2023 AJRCMB Junior Investigator Awards.
In recognition of their exemplary work, the AJRCMB editors are delighted to present the 2023 Journal Reviewer Award winners.
This page will serve as a hub for all COVID-19 related manuscripts published across all four ATS Journals.

Current Issue Highlights

The present article describes a useful, accessible animal model of respiratory OC43 coronavirus infection and assesses the effects of immune-modulating therapies on disease. The study provides a platform model that can support basic research to better understand the mechanisms underlying respiratory coronavirus infection, immune stimulation, and identification and development of novel therapies for coronavirus-induced diseases.
Karmaus and colleagues performed a meta-analysis of several independent publicly available BAL single-cell RNA sequencing datasets from patients with coronavirus disease (COVID-19) in an effort to enrich for new insights into pathogenesis. Pseudotemporal modeling of AT-II–to–AT-I progression revealed evidence for an AT-I cell state marked by the aberrant induction of multiple genes of the epidermal differentiation complex and a cornification signature. These findings identify new putative markers and potential pathophysiologic mechanisms of alveolar epithelial injury in human subjects with COVID-19.
The authors’ findings indicate that mouse Eos are a heterogeneous pool of cells with distinct activation states and spatiotemporal regulation during the resolution of type 2 inflammation and that RvD2 is a potent proresolving mediator for inflammatory Eos recruitment and activation.
The results define cells isolated within the so-called “golden hour of birth” in extremely premature neonate airways, representing complex lung biology, and can be used in studies of human development and disease.

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