Announcement
Congratulations Fernando J. Martinez, MD, MS, the new editor of the prestigious AJRCCM! Dr. Martinez succeeds Jadwiga Wedzicha, MD, ATSF. His editorship will begin Jan. 1, 2022.
AUGUST, 2021
ATS Journals
News & Announcements
In recognition of their exemplary work, the AJRCCM editors are delighted to present the 2021 Journal Reviewer Award winners. Awards are based on the number of completed reviews as well as the quality of their reviews, encompassing length and breadth. Congratulations to our cherished reviewers!
A new paper published in the American Journal of Respiratory and Critical Care Medicine examines microbiota profiles in the respiratory tract and their association with inflammation and acute respiratory failure in mechanically ventilated patients. The findings help shed light on the effect of the respiratory tract microbiome on a patient’s immune responses, opening doors to novel management approaches for such occurrences.
COVID-19 is a new form of Coronavirus disease due to the novel virus SARS-CoV2 that causes acute infection with respiratory symptoms. This page will serve as a hub for all COVID-19 related manuscripts published across all four ATS Journals.
Current Issue Highlights
Using blastocyst complementation and mouse–rat interspecies chimeras as “bioreactors,” the authors produced fully functional mouse FOXF1+cKIT+ EPCs from pluripotent ESCs. ESC-derived EPCs were fully competent to stimulate neonatal lung angiogenesis and alveolarization in a mouse model of alveolar capillary dysplasia with misalignment of pulmonary veins.
AUGUST 1, 2021
AJRCCM
Protocolized Postextubation Respiratory Support to Prevent Reintubation: A Randomized Clinical Trial
In the PROPER (Protocolized Post-Extubation Respiratory Support) trial, protocolized postextubation respiratory support, primarily characterized by the use of high-flow nasal cannula after extubation, did not prevent reintubation compared with usual care among a broad population of critically ill adults undergoing extubation from invasive mechanical ventilation at an academic medical center.
AUGUST 1, 2021
AJRCCM
In this study, the authors demonstrate that CD148 expressed in lung fibroblasts can confer antifibrotic effects in human and experimental pulmonary fibrosis. CD148-deficient fibroblasts exhibited hyperactivated PI3K/Akt/mTOR signaling, reduced autophagy, and increased p62 accumulation, leading to NF-κB activation, which they identify as a novel mechanism regulating profibrotic gene expression. CD148-targeting peptides can exert antifibrotic effects and show therapeutic potential in experimental and human fibrosis.
AUGUST 1, 2021
AJRCCM
Current Images Articles
<
The Unforeseen Path to the Superior Vena Cava
August 1, 2021Interpreting the Deep Sulcus Sign
August 1, 2021