| 1. | Wagenvoort C. A., Wagenvoort N.Primary pulmonary hypertension; a pathologic study of the lung vessels in 156 clinically diagnosed cases. Circulation4219701184 |
| 2. | Reid, L. M., and P. Davies. 1998. Control of cell proliferation in pulmonary hypertension. In E. K. Weir and J. T. Reeves, editors. Pulmonary Physiology and Pathophysiology. Marcel Dekker, New York. 541–611. |
| 3. | Loscalzo J.Endothelial dysfunction in pulmonary hypertension. N. Engl. J. Med.32719927075 |
| 4. | Dinh-Xuan A. T., Cremona G., Higenbottan T. W.Endothelial dysfunction and remodelling of the pulmonary circulation in chronic hypoxic pulmonary hypertension. Appl. Cardiopulm. Pathophysiol.519949399 |
| 5. | Tuder R. M., Groves B. M., Badesch D. B., Voelkel N. F.Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am. J. Pathol.1441994275285 |
| 6. | Cool C. D., Kennedy D., Voelkel N. F., Tuder R. M.Pathogenesis and evolution of plexiform lesions in pulmonary hypertension associated with scleroderma and human immunodeficiency virus infection. Hum. Pathol.281997434442 |
| 7. | Giaid A., Yanagisawa M., Langleben D., Michel R. P., Levy R., Shennib H., Kimura S., Masaki T., Duguid W. P., Stewart D. J.Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N. Engl. J. Med.328199317321739 |
| 8. | Voelkel N. F., Tuder R. M., Wade K., Hoper M., Lepley R. A., Goulet J. L., Koller B. H., Fitzpatrick F.Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats. J. Clin. Invest.97199624912498 |
| 9. | Wright L., Tuder R. M., Cool C. D., Lepley R. A., Voelkel N. F.5-Lipoxygenase and 5-lipoxygenase activating protein (FLAP) immunoreactivity in lungs from patients with primary pulmonary hypertension. Am. J. Respir. Crit. Care Med.1571998219229 |
| 10. | Badesch D. B., Orton E. C., Zapp L. M., Westcott J. Y., Hester J., Voelkel N. F., Stemnark K. R.Decreased arterial wall prostaglandin production in neonatal calves with severe chronic pulmonary hypertension. Am. J. Respir. Crit. Care Med.11989489498 |
| 11. | Alhenc-Gelas F., Tsai S. J., Callahan K. S., Campbell W. B., Johson A. R.Stimulation of prostaglandin formation by vasoactive mediators in cultured human endothelial cells. Prostaglandins241982723742 |
| 12. | Smith D. L., Dewitt D. L., Allen M. L.Bimodal distribution of the prostaglandin I2 synthase antigen in smooth muscle cells. J. Biol. Chem.258199359225926 |
| 13. | Gerber J. G., Voelkel N. F., Nies A. S., McMurtry I. F., Reeves J. T.Moderation of hypoxic vasoconstriction by infused arachidonic acid: role of PGI2. J. Appl. Physiol.491980107112 |
| 14. | Owen, N. E. 1985. Prostacyclin can inhibit DNA synthesis in vascular smooth muscle cells. In J. M. Bailey, editor. Prostaglandins, Leukotrienes and Lipoxins. Plenum Press, New York. |
| 15. | Hara S., Morishita R., Tone Y., Yokoyama C., Inoue H., Kaneda Y., Ogihira T., Tanabe T.Overexpression of prostacyclin synthase inhibits growth of vascular smooth muscle cells. Biochem. Biophys. Res. Commun.2161995862867 |
| 16. | Christman B. W., McPherson C. D., Newman J. H.An imbalance between the excretion of the thromboxane and prostacyclin metabolites in pulmonary hypertension. N. Engl. J. Med.32719927075 |
| 17. | Halbower A. C., Mason R. J., Abman S. H., Tuder R. M.Agarose infiltration improves morphology of cryostat sections of lung. Lab. Invest.711994149153 |
| 18. | Voelkel N. F., Tuder R. M., Bridges J., Arend W. P.Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline. Am. J. Respir. Cell Mol. Biol.111994664675 |
| 19. | Geraci, M. W., D. C. Shepherd, M. D. Moore, J. M. Shannon, and N. F. Voelkel. 1995. Rat prostacyclin synthase: developmental regulation and tissue specific expression. Circulation 92:I–375. |
| 20. | Geraci M. W., Miller Y. E., Escobedo-Morse A., Kane M. A.Novel bombesin-like peptide binding proteins from lung. Am. Respir. Cell Mol. Biol.101995331338 |
| 21. | Pereira B., Wu K. K., Wang L. H.Bovine prostacyclin synthase: purification and isolation of partial cDNA. Biochem. Biophys. Res. Commun.197199310411048 |
| 22. | Villamor E., Le C. D., Horan M. P., Halbower A. C., Tuder R. M., Abman S. H.Chronic intrauterine pulmonary hypertension impairs endothelial nitric oxide synthase in the ovine fetus. Am. J. Physiol.2721997L1013L1020 |
| 23. | Siegle I., Nusing R., Brugger R., Sprenger R., Zecher R., Ulrich V.Characterization of monoclonal antibodies generated against bovine and porcine prostacyclin synthase and quantitation of bovine prostacyclin synthase. FEBS Lett.3471994221225 |
| 24. | Giaid A., Saleh D.Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N. Engl. J. Med.3331995214221 |
| 25. | Xue C., Johns R. A.Endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N. Engl. J. Med.333199516421644 |
| 26. | Mason N. A., Springall D. R., Burke M., Pollock J., Mikhail G., Yacoub M. H., Polak J. M.High expression of endothelial nitric oxide synthase in plexiform lesions of pulmonary hypertension. J. Pathol.1851998313318 |
| 27. | Isaacson T. C., Hampl V., Weir E. K., Nelson D. P., Archer S. L.Increased endothelium-derived NO in hypertensive pulmonary circulation of chronically hypoxic rats. J. Appl. Physiol.761994933940 |
| 28. | Le C., Xue C., Rengasamy A., Johns R. A.Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung. Am. J. Physiol.2701996L164L170 |
| 29. | Nichols W. C., Koller D. L., Slovis B., Foroud T., Terry V. H., Arnold N. D., Siemieniak D. R., Wheeler L., Phillips J. A., Newman J. H., Conneally P. M., Ginsburg D., Loyd J. E.Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31–32. Nature Genet.151997277280 |
| 30. | Lee S. D., Shroyer K. R., Markham N. E., Cool C. D., Voelkel N. F., Tuder R. M.Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension. J. Clin. Invest.1011998927934 |
