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Heather L. Rossi, Jorge F. Ortiz-Carpena, Devon Tucker, Andrew E. Vaughan, Nilam S. Mangalmurti, Noam A. Cohen, De’Broski R. Herbert. (2022) Trefoil Factor Family: A Troika for Lung Repair and Regeneration. American Journal of Respiratory Cell and Molecular Biology 66:3, 252-259.
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Albert C. Pai, Thomas J. Lynch, Bethany A. Ahlers, Vitaly Ievlev, John F. Engelhardt, Kalpaj R. Parekh. (2022) A Novel Bioreactor for Reconstitution of the Epithelium and Submucosal Glands in Decellularized Ferret Tracheas. Cells 11:6, 1027.
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Albert C. Pai, Kalpaj R. Parekh, John F. Engelhardt, Thomas J. Lynch. 2021. Ferret respiratory disease models for the study of lung stem cells. Lung Stem Cells in Development, Health and Disease.
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Lynda S Ostedgaard, Margaret P Price, Kristin M Whitworth, Mahmoud H Abou Alaiwa, Anthony J Fischer, Akshaya Warrier, Melissa Samuel, Lee D Spate, Patrick D Allen, Brieanna M Hilkin, Guillermo S Romano Ibarra, Miguel E Ortiz Bezara, Brian J Goodell, Steven E Mather, Linda S Powers, Mallory R Stroik, Nicholas D Gansemer, Camilla E Hippee, Keyan Zarei, J Adam Goeken, Thomas R Businga, Eric A Hoffman, David K Meyerholz, Randall S Prather, David A Stoltz, Michael J Welsh. (2020) Lack of airway submucosal glands impairs respiratory host defenses. eLife 9.
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Yinghua Tang, Ziying Yan, John F. Engelhardt. (2020) Viral Vectors, Animal Models, and Cellular Targets for Gene Therapy of Cystic Fibrosis Lung Disease. Human Gene Therapy 31:9-10, 524-537.
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Andreas Frey, Lars P. Lunding, Johanna C. Ehlers, Markus Weckmann, Ulrich M. Zissler, Michael Wegmann. (2020) More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis. Frontiers in Immunology 11.
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M M Leiva-Juárez, J K Kolls, S E Evans. (2018) Lung epithelial cells: therapeutically inducible effectors of antimicrobial defense. Mucosal Immunology 11:1, 21-34.
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Britton C. Goodale, Erica J. Rayack, Bruce A. Stanton. (2017) Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells. Toxicology and Applied Pharmacology 331, 154-163.
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Preston J. Anderson, Thomas J. Lynch, John F. Engelhardt. (2017) Multipotent Myoepithelial Progenitor Cells Are Born Early during Airway Submucosal Gland Development. American Journal of Respiratory Cell and Molecular Biology 56:6, 716-726.
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Kang-Mu Lee, Keehoon Lee, Junhyeok Go, In Ho Park, Jeon-Soo Shin, Jae Young Choi, Hyun Jik Kim, Sang Sun Yoon. (2017) A Genetic Screen Reveals Novel Targets to Render Pseudomonas aeruginosa Sensitive to Lysozyme and Cell Wall-Targeting Antibiotics. Frontiers in Cellular and Infection Microbiology 7.
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Hiroyuki Ohbayashi, Yasuhiro Setoguchi, Yoshinosuke Fukuchi, Kai Shibata, Yukinori Sakata, Toshihisa Arai. (2016) Pharmacological effects of lysozyme on COPD and bronchial asthma with sputum: A randomized, placebo-controlled, small cohort, cross-over study. Pulmonary Pharmacology & Therapeutics 37, 73-80.
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Jonathan H. Widdicombe, Jeffrey J. Wine. (2015) Airway Gland Structure and Function. Physiological Reviews 95:4, 1241-1319.
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Abstract | Full Text | PDF (1106 KB) | Supplemental Material
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Jibin Zhang, Jinsoo Ahn, Yeunsu Suh, Seongsoo Hwang, Michael E. Davis, Kichoon Lee, Jonathan Peterson. (2015) Identification of CTLA2A, DEFB29, WFDC15B, SERPINA1F and MUP19 as Novel Tissue-Specific Secretory Factors in Mouse. PLOS ONE 10:5, e0124962.
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Kamen Rangelov, Sanjay Sethi. (2014) Role of Infections. Clinics in Chest Medicine 35:1, 87-100.
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Yanyan Liu, Marissa E. Di, Hong Wei Chu, Xinyu Liu, Ling Wang, Sally Wenzel, Y. Peter Di. (2013) Increased Susceptibility to Pulmonary
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Nicholas W. Keiser, John F. Engelhardt. (2013) Gene Delivery to the Airway. Current Protocols in Human Genetics 78:1.
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Karin Provost, Himanshu Desai, Sanjay Sethi. 2013. Infectious Mechanisms Regulating Susceptibility to Acute Exacerbations of COPD. Smoking and Lung Inflammation, 159-176.
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Sam Jacob, Yong Zhu, Collette Jonkam, Sven Asmussen, Lillian Traber, David N. Herndon, Tina L. Palmieri, Perenlei Enkhbaatar, Daniel L. Traber, Hal K. Hawkins, Robert A. Cox. (2013) Effect of Bronchodilators on Bronchial Gland Cell Proliferation After Inhalation and Burn Injury in Sheep. Journal of Burn Care & Research 34:4, 386-393.
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Shilpa E George, Ravisha Chikkamadaiah, Murali Durgaiah, Amruta A Joshi, Ullas P Thankappan, Shampur N Madhusudhana, Bharathi Sriram. (2012) Biochemical characterization and evaluation of cytotoxicity of antistaphylococcal chimeric protein P128. BMC Research Notes 5:1.
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Nicholas Baniak, Xiaojie Luan, Amber Grunow, Terry E. Machen, Juan P. Ianowski. (2012) The cytokines interleukin-1β and tumor necrosis factor-α stimulate CFTR-mediated fluid secretion by swine airway submucosal glands. American Journal of Physiology-Lung Cellular and Molecular Physiology 303:4, L327-L333.
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Nicholas W. Keiser, John F. Engelhardt. (2011) New animal models of cystic fibrosis. Current Opinion in Pulmonary Medicine 17:6, 478-483.
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Zi-Qiang Zhang, Yuan-Lin Song, Zhi-Hong Chen, Yao Shen, Chun-Xue Bai. (2011) Deletion of Aquaporin 5 Aggravates Acute Lung Injury Induced by Pseudomonas aeruginosa. Journal of Trauma: Injury, Infection & Critical Care 71:5, 1305-1311.
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Ganapathi Iyer Parameswaran, Sanjay Sethi, Timothy F. Murphy. (2011) Effects of Bacterial Infection on Airway Antimicrobial Peptides and Proteins in COPD. Chest 140:3, 611-617.
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Hyung-Ju Cho, Nam Soo Joo, Jeffrey J. Wine, Neeraj Vij. (2011) Defective Fluid Secretion from Submucosal Glands of Nasal Turbinates from CFTR-/- and CFTRΔF508/ΔF508 Pigs. PLoS ONE 6:8, e24424.
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Dane Parker, Alice Prince. (2011) Innate Immunity in the Respiratory Epithelium. American Journal of Respiratory Cell and Molecular Biology 45:2, 189-201.
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Abstract | Full Text | PDF (323 KB)
Online publication date: 20-Dec-2012.
Abstract | Full Text | PDF (323 KB)
Weiliang Xie, John T. Fisher, Thomas J. Lynch, Meihui Luo, Turan I.A. Evans, Traci L. Neff, Weihong Zhou, Yulong Zhang, Yi Ou, Nigel W. Bunnett, Andrew F. Russo, Michael J. Goodheart, Kalpaj R. Parekh, Xiaoming Liu, John F. Engelhardt. (2011) CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice. Journal of Clinical Investigation 121:8, 3144-3158.
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K. Bloemen, R. Van Den Heuvel, E. Govarts, J. Hooyberghs, V. Nelen, E. Witters, K. Desager, G. Schoeters. (2011) A new approach to study exhaled proteins as potential biomarkers for asthma. Clinical & Experimental Allergy 41:3, 346-356.
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Monal Khansaheb, Jae Young Choi, Nam Soo Joo, Yu-Mi Yang, Mauri Krouse, Jeffrey J. Wine. (2011) Properties of substance P-stimulated mucus secretion from porcine tracheal submucosal glands. American Journal of Physiology-Lung Cellular and Molecular Physiology 300:3, L370-L379.
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Kerry McGarr Empey, Jay K. Kolls. 2011. Neonatal Pulmonary Host Defense. Fetal and Neonatal Physiology, 1701-1744.
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Alejandro A. Pezzulo, Timothy D. Starner, Todd E. Scheetz, Geri L. Traver, Ann E. Tilley, Ben-Gary Harvey, Ronald G. Crystal, Paul B. McCray, Joseph Zabner. (2011) The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia. American Journal of Physiology-Lung Cellular and Molecular Physiology 300:1, L25-L31.
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Thomas C. Scanlon, Charlotte C. Teneback, Avinash Gill, Jenna L. Bement, Joshua A. Weiner, John W. Lamppa, Laurie W. Leclair, Karl E. Griswold. (2010) Enhanced Antimicrobial Activity of Engineered Human Lysozyme. ACS Chemical Biology 5:9, 809-818.
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Online publication date: 23-Jul-2010.
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Xingshen Sun, Hongshu Sui, John T. Fisher, Ziying Yan, Xiaoming Liu, Hyung-Ju Cho, Nam Soo Joo, Yulong Zhang, Weihong Zhou, Yaling Yi, Joann M. Kinyon, Diana C. Lei-Butters, Michelle A. Griffin, Paul Naumann, Meihui Luo, Jill Ascher, Kai Wang, Timothy Frana, Jeffrey J. Wine, David K. Meyerholz, John F. Engelhardt. (2010) Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis. Journal of Clinical Investigation 120:9, 3149-3160.
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Hyung-Ju Cho, Nam Soo Joo, Jeffrey J. Wine. (2010) Mucus secretion from individual submucosal glands of the ferret trachea. American Journal of Physiology-Lung Cellular and Molecular Physiology 299:1, L124-L136.
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C Mueller, M S Strayer, J Sirninger, S Braag, F Branco, J-P Louboutin, T R Flotte, D S Strayer. (2010) In vitro and in vivo functional characterization of gutless recombinant SV40-derived CFTR vectors. Gene Therapy 17:2, 227-237.
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Jae Young Choi, Monal Khansaheb, Nam Soo Joo, Mauri E. Krouse, Robert C. Robbins, David Weill, Jeffrey J. Wine. (2009) Substance P stimulates human airway submucosal gland secretion mainly via a CFTR-dependent process. Journal of Clinical Investigation 119:5, 1189-1200.
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Mehmet Kesimer, Sara Kirkham, Raymond J. Pickles, Ashley G. Henderson, Neil E. Alexis, Genevieve DeMaria, David Knight, David J. Thornton, John K. Sheehan. (2009) Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways?. American Journal of Physiology-Lung Cellular and Molecular Physiology 296:1, L92-L100.
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Hannes Kutta, Andreas Willer, Philipp Steven, Lars Bräuer, Michael Tsokos, Friedrich Paulsen. (2008) Distribution of mucins and antimicrobial substances lysozyme and lactoferrin in the laryngeal subglottic region. Journal of Anatomy 213:4, 473-481.
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Yen‐Ta Lu, Chia‐Li Han, Chien‐Liang Wu, Tien‐Min Yu, Chih‐Wei Chien, Ching‐Lung Liu, Yu‐Ju Chen. (2008) Proteomic profiles of bronchoalveolar lavage fluid from patients with ventilator‐associated pneumonia by gel‐assisted digestion and 2‐D‐LC/MS/MS. PROTEOMICS – Clinical Applications 2:9, 1208-1222.
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Abstract | Full Text | PDF (499 KB)
Online publication date: 20-Dec-2012.
Abstract | Full Text | PDF (499 KB)
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Online publication date: 20-Dec-2012.
Abstract | Full Text | PDF (889 KB) | Supplemental Material
Online publication date: 20-Dec-2012.
Abstract | Full Text | PDF (889 KB) | Supplemental Material
Jin V. Wu, Mauri E. Krouse, Jeffrey J. Wine. (2007) Acinar origin of CFTR-dependent airway submucosal gland fluid secretion. American Journal of Physiology-Lung Cellular and Molecular Physiology 292:1, L304-L311.
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Abstract | Full Text | PDF (210 KB)
Online publication date: 20-Dec-2012.
Abstract | Full Text | PDF (210 KB)
Jeffrey J. Wine. (2006) Acid in the airways.
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