Periodic breathing (PB) during exercise in patients with congestive heart failure (CHF) is associated with prominent oscillations (OSC) of O2 uptake (O2). We hypothesized that the
O2 OSC represent OSC in true O2 exchange, resulting from concomitant cardiac output fluctuations and are not merely due to OSC of lung O2 stores. We compared the amplitude of the OSC of
O2, ventilation (
e), and end-expiratory lung volume (EELV) in 17 patients with CHF and PB and in seven healthy control subjects who volitionally simulated PB. Subjects underwent an incremental and/or a constant work-rate exercise test.
e and
O2 were measured breath by breath. EELV change was estimated by summing the difference between inspiratory and expiratory tidal volumes for each breath. The amplitude of the OSC, Δ, is expressed as the ratio of the difference between the peak and nadir of the oscillating variable divided by its mean [Δ = (peak - nadir)/mean]. In CHF, during incremental testing, the amplitude of the
e OSC was smaller than that of the
O2 OSC (Δ
e = 49 ± 15% [SD], Δ
O2 = 63 ± 25%, p < 0.01). In contrast, during volitional PB in the control subjects,
e OSC were larger than
O2 OSC (Δ
e = 48 ± 12%, Δ
O2 = 25 ± 11%, p < 0.01). This suggests that changing
e Itself cannot account for the marked
O2 OSC seen in CHF. In the patients, EELV showed no systematic OSC, did not correlate with Δ
O2, and was not significantly different from zero. In contrast, in the control subjects, EELV tended to be lower at peak
e (−0.14 ± 0.5 L, p = 0.06), and it was well correlated with Δ
O2 (r = 0.6, p < 0.01). In conclusion,
O2 oscillations in patients with CHF are more prominent than the associated
e OSC, are greater than the
O2 OSC that can be induced by volitional PB, and are not associated with changes in EELV. This supports the hypothesis that cardiac output OSC contribute to
O2 OSC.