* These authors contributed equally to this work.

Supported by Driscoll Children’s Fund Scholar (N.V.D.), the Louis V. Gerstner Jr. Scholarship Fund (N.V.D.), the Stony Wold-Herbert Fund (N.V.D.), and National Heart, Lung, and Blood Institute grant U01HL134760-07 (N.V.D., co-investigator).

Author Contributions: C.P., D.I., and N.V.D. designed the study. C.P. and D.I. optimized the code with T.S. and validated on mouse (D.I.), rat, human, and pig (C.P.). C.P., D.I., A.S., T.S., and N.V.D. interpreted and analyzed the data. N.V.D. wrote the manuscript with support from C.P., M.L.M., T.S., and A.S. All the authors read and approved the final manuscript.

This letter has a data supplement, which is accessible from this issue’s table of contents at www.atsjournals.org.

Author disclosures are available with the text of this letter at www.atsjournals.org.