American Journal of Respiratory Cell and Molecular Biology

An improved understanding of the human lung necessitates advanced systems models informed by an ever-increasing repertoire of molecular omics, cellular imaging, and pathological datasets. To centralize and standardize information across broad lung research efforts, we expanded the LungMAP.net website into a new gateway portal. This portal connects a broad spectrum of research networks, bulk and single-cell multiomics data, and a diverse collection of image data that span mammalian lung development and disease. The data are standardized across species and technologies using harmonized data and metadata models that leverage recent advances, including those from the Human Cell Atlas, diverse ontologies, and the LungMAP CellCards initiative. To cultivate future discoveries, we have aggregated a diverse collection of single-cell atlases for multiple species (human, rhesus, and mouse) to enable consistent queries across technologies, cohorts, age, disease, and drug treatment. These atlases are provided as independent and integrated queryable datasets, with an emphasis on dynamic visualization, figure generation, reanalysis, cell-type curation, and automated reference-based classification of user-provided single-cell genomics datasets (Azimuth). As this resource grows, we intend to increase the breadth of available interactive interfaces, supported data types, data portals and datasets from LungMAP, and external research efforts.

Correspondence and requests for reprints should be addressed to Nathan Salomonis, Ph.D., Cincinnati Children's Hospital Medical Center, 3333 Burnett Avenue, Cincinnati, Ohio 45229. E-mail: .

*These authors contributed equally to this work.

Data Advisor to California Institute for Regenerative Medicine.

Supported by the National Heart, Lung, and Blood Institute (U01HL122700 [G.S.P.], U01HL148856 [J.A.W. and Y.X.], U01HL148857 [E.E.M.], U01HL148860 [J.P.C., G.C.C., and J.A.], U01HL148861 [G.S.P.], U01HL148867 [X.S.], and U24HL148865 [T.T., B.P., B.J.A., and N.S.]) and the National Human Genome Research Institute (U41HG010972 [B.P.], R01HG010485 [B.P.] , U24HG010262 [B.P.], and U24HG011853 [B.P.]).

Author Contributions: Conception and design: N.G., J.F., M.G., E.E.B., M.K., S.T., K.B., M.E.A.-P., S.L., D.S., K.J., B.I., Y.D., B.-X.H., A.B., J.K., R.M., V.S., A.H., J.A.K., G.C.C., J.P.C., J.A., E.E.M., G.S.P., R.M., J.A.W., X.S., T.H., B.P., V.B.S.P., Y.X., T.T., B.J.A., and N.S. Drafting the manuscript for important intellectual content: N.G., J.F., J.A.W., G.S.P., R.M., V.B.S.P., Y.X., T.T., B.J.A., and N.S.

This article has a related editorial.

This article has a data supplement, which is accessible from this issue’s table of contents at www.atsjournals.org.

Originally Published in Press as DOI: 10.1165/rcmb.2022-0165OC on November 22, 2022

Author disclosures are available with the text of this article at www.atsjournals.org.

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American Journal of Respiratory Cell and Molecular Biology
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